1. The very short food-pipe between the mouth and the stomach of the infant may facilitate regurgitation
2. Babies have very small stomachs and with rapid feeding or high volume feeding, the small stomach capacity rapidly fills. This, especially in association with lower oesophageal sphincter relaxation, can contribute to regurgitation
3. Normally, more than 90% of refluxed volume can be cleared from the Oesophagus by one or two normal peristaltic waves. Motor abnormalities associated with immaturity may result in failed peristaltic contractions, thereby, permitting regurgitation
4. resulting either as hypotonia (insufficient muscle tone) or undeveloped control mechanisms (nervous system development) which allows transient relaxation. This permits easy flow of stomach contents back up to the food-pipe into the mouth (gastro-oesophageal reflux), where it dribbles effortlessly out of the mouth, the typical symptom known as "regurgitation".
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